Three long years of starvation, sufferings and sickness made Khadija and Abu Talib (A.S.) so weak that both died within three days of their return to Mecca. These two deaths were a great blow to the Prophet (S.A.W) and his mission. Everything looked dark and dismal. The Prophet (S.A.W) was now without a guardian and Ali (A.S.) without a father. The loss of Khadija was also a big loss to both of them. She had given twenty eight years of her life and all that she possessed to Mohammad (S.A.W) to spend on the cause of Islam, and Ali (A.S.) had lost a mother in whose laps he had grown.

The Prophet (S.A.W) always remembered Khadija and moaned, "Never did Allah give me a better wife than Khadija. She hailed my mission at a time when everybody shouted against it. She lent me the support of her conviction when there was hardly a believer. She enlivened my heart when I felt lonely and deserted. Khadija’s love was given to me by Allah. How could I forget her." Khadija died at the age of sixty five. She belonged to the most respectable clan of Quraish and was called Tahera (pure) the Arabs gave her the title of "The leader of the ladies." She was so bold and courageous that she managed the entire business of her father herself as he was very old. From Khadija the Prophet (S.A.W) got one son Qasim and one daughter Fatema (S.A.). Qasim was born before the advent of Islam and died in his infancy. But the Arabs always addressed the Prophet (S.A.W) as Abul Qasim.

The Prophet (S.A.W) was left alone with Ali (A.S.) and his daughter Fatema (S.A.) who was just eight years old. But she took care of her father and managed the affairs of his house hold. She served him taking minutest details of needs and requirements. Whenever he returned home with his head covered with dust and dirt thrown by the infidels, or wounded by the stones pelted at him, Fatema (S.A.) would wash his head and dress his wounds. The Prophet (S.A.W) speaking about Fatema (S.A.) said, "Fatema is a part of my body. Whoever angers her, angers me." [Sahih Muslim]. He respected her so much that whenever she came to meet him he stood up in respect to receive her and said Marhaba (Sahih Bukhari]. He called her the leader of the women of the universe and the leader of the ladies of heaven [Musnad Imam Hanbal]. Aisha (one of the wives of the Prophet (S.A.W)) speaking about Fatema (S.A.) said,"I have never seen a more truthful person than Fatema and her father." [Abu Noaim Isfahani].